In reply to Rick Wicklin.

Thanks for taking the time to respond! You have great resources and I've been learning a lot. I actually *did* get the advice from a senior statistician to use the approach I mentioned who works often with clinical scientists and has seen the method used in published work and among colleagues. I look forward to learning more about different approaches by different researchers to find the best approach. I can cross off Winsorization from the list of options!