In reply to Rick Wicklin.

Thanks! Yes, I suppose the information criterion would be that a) only three models can be used; b) each observed sequence will be compared to only one of the three models; and c) total variance of "system-to-model" must be minimized. The tricky thing is that the model sequences are not given, nor are the pairings of observed sequences with model sequences. Those things must be calculated. Since H/T is binary, I believe we should be able to calculate those things mathematically, just not sure how. Maybe a clustering algorithm?

Anyways, thanks for the quick response on a thread that is now...7 years old!