In reply to Rick Wicklin.

So if I have two groups (placebo vs active) and 5 timepoints (i.e., 4 trapezoids) for a measurement scale. Several of the subjects are missing the last 1-2 timepoints. If I sum the values of the trapezoids to a final AUC for each subject, can I simply compare mean AUC's with a t-test (assuming normally distributed)?.

If so, some of the total AUCs will be much smaller because of missing values--how can I handle this post hoc?